-synuclein, which is a main part of Lewy bodies, in PARK one in 1997 and parkin in PARK 2 in 1998, that is an E3 ubiquitin ligase and will cause endoplasmic reticulum (ER) pressure, counsel that dysfunction of your intracellular proteinase programs, for example ubiquitin-proteasome method or lysosomal method, which eliminates needless toxic protein

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